Factors Influencing Ascertainment Bias of Microsatellite Allele Sizes: Impact on Estimates of Mutation Rates
نویسندگان
چکیده
منابع مشابه
Factors influencing ascertainment bias of microsatellite allele sizes: impact on estimates of mutation rates.
Microsatellite loci play an important role as markers for identification, disease gene mapping, and evolutionary studies. Mutation rate, which is of fundamental importance, can be obtained from interspecies comparisons, which, however, are subject to ascertainment bias. This bias arises, for example, when a locus is selected on the basis of its large allele size in one species (cognate species ...
متن کاملFactors in uencing ascertainment bias of microsatellite allele sizes: impact on estimates of mutation rates
Microsatellite loci play an important role as markers for identi cation, disease gene mapping and evolutionary studies. Mutation rate, which is of fundamental importance, can be obtained from interspecies comparisons, which however are subject to ascertainment bias. This bias arises for example when a locus is selected based on its large allele size in one species (cognate species 1), in which ...
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15 صفحه اولImpact of Marker Ascertainment Bias on Genomic Selection Accuracy and Estimates of Genetic Diversity
Genome-wide molecular markers are often being used to evaluate genetic diversity in germplasm collections and for making genomic selections in breeding programs. To accurately predict phenotypes and assay genetic diversity, molecular markers should assay a representative sample of the polymorphisms in the population under study. Ascertainment bias arises when marker data is not obtained from a ...
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ژورنال
عنوان ژورنال: Genetics
سال: 2013
ISSN: 1943-2631
DOI: 10.1534/genetics.113.154161